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Evidence synthesis

Research theme leads

  • Daniela De Angelis, Dr (University of Cambridge MRC Biostatistics Unit)
  • André Charlett, Dr (Public Health England)
University library


About this theme

This workstream provides systematic review capacity for the HPRU, and uses Multiple Parameter Evidence Synthesis (MPES) to support public health surveillance and evaluation of health care programmes.

Research areas 

Estimating hepatitis burden in England and the UK

Our research focuses on two fronts:

  1. Improving the evidence base for commissioning Hepatitis C (HCV) services by developing estimates of HCV prevalence for specific areas starting with the East of England and Scotland
  2. Estimating the impact of providing direct acting antiviral (DDA) to HCV-infected individuals at different stages of the disease, in England.

Systematic reviews

We undertake and support full and rapid systematic reviews on health protection priorities. Reviews are undertaken in collaboration with topic leads in Public Health England’s Field Epidemiology Service, and other internal and external groups.

Research examples

Current

Prevalence and burden of hepatitis B co-infection among people living with HIV: a global systematic review and meta-analysis.

Cannabis use and the risk of tuberculosis: a systematic review.

Impact of opioid substitution therapy (OST) on HIV testing among people who have recently injected drugs: a systematic review and meta-analysis.

Systematic review and network meta-analysis on therapeutic interventions for alcohol dependence in community settings

Completed

Needle syringe programmes and opioid substitution therapy for preventing HCV transmission among people who inject drugs: findings from a Cochrane Review and meta-analysis

Control of carbapenemase-producing Enterobacteriaceae outbreaks in acute settings: An evidence review.

Effectiveness of needle/syringe programmes and opiate substitution therapy in preventing HCV transmission among people who inject drugs

Impact of opioid substitution therapy on antiretroviral therapy outcomes: a systematic review and meta-analysis

Risk of nosocomial respiratory syncytial virus infection and effectiveness of control measures to prevent transmission events: a systematic review

Effectiveness of needle/syringe programmes and opiate substitution therapy in preventing HCV transmission among people who inject drugs (Protocol)

Research team